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https://www.nature.com/articles/s43016-021-00430-6.epdf?sharing_token=wrDnSGSrPhPXzO_pVhcBytRgN0jAjWel9jnR3ZoTv0PPCB6ksI-JBK7ICKjPGCIfGgUPdxTYW8qNQJkrLw0lVixtt1xz9hODtY1hNFwlX57JfnqIT33MqYYVKDmQvvfE409toZ4dQZ3HCv_YOZbA7OFGhNmegXuJXDXzxMiMFJk%3D